What Vaccines Do Kittens Need. The first series of shots a kitten will usually get is a drcc/fvrcp vaccination against feline distemper (panleukopenia), rhinotracheitis, and calici virus. To help protect kittens they'll need two sets of vaccinations to get them started.
There are a few things you should do right away to be sure your new kitten is free of parasites and viruses: All kittens should receive vaccines for rabies, upper respiratory infections and distemper. Generally, all cats should be vaccinated against feline viral rhinotracheitis, calicivirus and panleukopenia.
Don't assume that your cat doesn't need at least some vaccines just because he doesn't go outside.
All kittens should receive vaccines for rabies, upper respiratory infections and distemper. Core vaccines are considered essential for kittens in most geographical locations. What do vaccinations protect against? All kittens need vaccinations to help keep them healthy.